Product Information

The BioFlo 510 is a compact sterilizable-in-place fermentation system ideal for pilot to small scale production processes. The modular design features a wide variety of standard options allowing this system to be flexible enough to meet most process requirements.

Gas flow
› Various combinations of two, three or four TMFCs:
0.06  –  3 SLPM
0.3  – 15 SLPM
0.6 –  32 SLPM
1  –  64 SLPM
› Overlay with TMFC (0 – 15 or 0 –  32 SLPM)
› Air Wash System with TMFC (0 – 15 or 0  – 32 SLPM)
› Overlay valve only

Exhaust line
› Exhaust condenser
› Automatic pressure control

Impellers
› Rushton-type – Used commonly for robust cell lines such as bacteria, yeasts and algae, where maximum OTR is desired. Provided as standard on BioFlo 510 fermentors
› Pitched-blade – Commonly used with mammalian, insect or other shear sensitive cell lines for batch, fed-batch, or continuous cultures. Produces axial and radial mixing
› Marine – Commonly used with mammalian, insect or other shear sensitive cell lines for batch, fed-batch, or continuous cultures. Produces axial mixing
› Spin Filter – For Suspension or Microcarrier cultures where a dip tube inside the filter withdraws cell media as harvest or waste
› Cell Lift – Specially designed to provide uniform circulation for both suspension and microcarrier cultures. Can be used with optional decanting columns for perfusion cultures (40 L only)
› Packed-bed basket – For secreted products from anchorage-dependent and suspension cells, this impeller immobilizes cells in a bed of Fibra-Cel^® disks to provide extremely high cell densities (40 L only)

Probes
› Single or redundant pH/DO control
› Redox control
› Foam/level detection

Addition and sampling
› Resterilizable sampling valve
› Resterilizable addition valves (4 max)
› Resterilizable addition/harvest valve with dip tube (2 max)
› 1.5 in sanitary fitting 7-port septum
› Addition vessels (glass/stainless steel)
› Decanters
› Sterile sampling assembly (kit of 3)

SCADA software
› BioCommand^® Track and Trend
› BioCommand Batch Control
› BioCommand Batch Control Plus

Validation
› Basic Package
› Basic Plus Package
› Enhanced Package

Utility regulator and pre-filter kits
› Process air pre-filter/regulator kit
› Instrument air pre-filter/regulator kit
› Water pre-filter/regulator kit
› Process steam regulator kit
› Utility steam pre-filter/regulator kit
› Utility connection kit

Additional options
› Allen Bradley^® CompactLogix™ PLC Control System
› Sprayballs for clean-in-place of vessel
› External variable-speed pumps
› External scales
› 8-port serial controller (RS-232)
› Spare parts kits
› Preventative maintenance kits
› Mobile table
› System passivation