SIP benchtop reactors designed to meet the needs of R&D through production
Product Information
The CelliGen 510 is a compact sterilizable-in-place cell culture system ideal for pilot to small scale production processes. The modular design features a wide variety of standard options allowing this system to be flexible enough to meet most process requirements.
Gas flow
› Various combinations of two, three or four TMFCs:
0.06 – 3 SLPM
0.3 – 15 SLPM
0.6 – 32 SLPM
1 – 64 SLPM
› Overlay with TMFC (0 – 15 or 0 – 32 SLPM)
› Air Wash System with TMFC (0 – 15 or 0 – 32 SLPM)
› Overlay valve only
Exhaust line
› Exhaust condenser
› Automatic pressure control
Impellers
› Pitched-blade – Commonly used with mammalian, insect or other shear sensitive cell lines for batch, fed-batch, or continuous cultures. Produces axial and radial mixing
› Marine – Commonly used with mammalian, insect or other shear sensitive cell lines for batch, fed-batch, or continuous cultures. Produces axial mixing
› Spinfilter – For suspension or microcarrier cultures where a dip tube inside the filter withdraws cell media as harvest or waste
› Cell-Lift – Specially designed to provide uniform circulation for both suspension and microcarrier cultures. Can be used with optional decanting columns for perfusion cultures (40 L only)
› Packed-bed basket – For secreted products from anchorage-dependent and suspension cells, this impeller immobilizes cells in a bed of Fibra-Cel® disks to provide extremely high cell densities (40 L only)
Probes
› Single or redundant pH/DO control
› Redox control
› Foam/level detection
Addition and sampling
› Resterilizable sampling valve
› Resterilizable addition valves (4 max)
› Resterilizable addition/harvest valve with dip tube (2 max)
› 1.5 in sanitary fitting 7-port septum
› Addition vessels (glass/stainless steel)
› Decanters
› Sterile sampling assembly (kit of 3)
SCADA software
› BioCommand® Track and Trend
› BioCommand Batch Control
› BioCommand Batch Control Plus
Validation
› Basic Package
› Basic Plus Package
› Enhanced Package
Utility regulator and pre-filter kits
› Process air pre-filter/regulator kit
› Instrument air pre-filter/regulator kit
› Water pre-filter/regulator kit
› Process steam regulator kit
› Utility steam pre-filter/regulator kit
› Utility connection kit
Additional options
› Allen Bradley® CompactLogix™ PLC Control System
› Sprayballs for clean-in-place of vessel
› External variable-speed pumps
› External scales
› 8-port serial controller (RS-232)
› Spare parts kits
› Preventative maintenance kits
› Mobile table
› System passivation
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